Poster presents findings of a study of ~1000 patient samples demonstrating superior accuracy for HemeScreen™ MPN Assay
NEW HAVEN, CT, Globenewswire – (November 7th, 2022) – Specialty cancer diagnostics company Precipio, Inc. (NASDAQ: PRPO) presented at the annual 2022 AMP conference a poster presentation of the results of a groundbreaking study, conducted in collaboration with faculty at the University of Pennsylvania. The study, expected to be published in detail early next year, demonstrates the superior results of Precipio’s HemeScreen® MPN panel when compared to Sanger Sequencing (considered the “gold standard” of molecular testing).
The study was co-authored by Dr. Christopher Sande, Resident Physician at University of Pennsylvania, Dr. Kojo Elenitoba-Johnson, formerly Professor of Pathology and Director of the Center for Personalized Diagnostics at the University of Pennsylvania and currently Chair of the Department of Pathology and Laboratory Medicine at Memorial Sloan Kettering Cancer Center in New York City, and several members of Precipio’s scientific team.
The goal of the study was to assess the accuracy of the HemeScreen technology by conducting blinded, side-by-side evaluation of patient samples with known results using two technologies. In the study, 982 patient samples were tested for the same genes using HemeScreen MPN panel, and Sanger Sequencing, considered the platform with the highest level of reliability and accuracy.
The study demonstrated concordance of greater than 99% between the two technologies, with a variance of six samples where the HemeScreen assay detected a mutation, while the Sanger assay did not. This concordance, and the variance, are due to the increased sensitivity and specificity of the HemeScreen assay (2~5% Limit of detection for HemeScreen vs. 10~15% for Sanger). This outcome demonstrates the superior performance of HemeScreen over Sanger in terms of diagnostic accuracy.
As stated in the poster conclusions section, results demonstrated “exquisite accuracy, sensitivity and specificity of the HemeScreen MPN assay in detecting genetic variants observed in MPN”. Furthermore, the “technology offers an opportunity for a low-cost approach with a simplified workflow for laboratories while providing a quick turnaround time, and accurate results”. For more information and to view the complete poster, please click here.
“This is the first peer-reviewed poster on HemeScreen®, accepted by the most recognized association in our field, and we are honored to have collaborated with faculty at UPenn to present such exciting findings”, said Ilan Danieli, CEO of Precipio. “This poster solidifies the accuracy of the assay, and further highlights the benefits to laboratories of using this innovative technology. I’m proud to be part of the team that created a product that has already impacted thousands of patients”.
The AMP annual conference is globally recognized as the largest event focused on molecular diagnostics. Precipio’s booth was visited by dozens of potential and current customers, and the company has seen significant interest that will translate into continued growth of its business. The support of such an academically and clinically recognized association through the acceptance of its poster submission strengthens the value proposition of HemeScreen to the market.
Precipio has built a platform designed to eradicate the problem of misdiagnosis by harnessing the intellect, expertise and technology developed within academic institutions and delivering quality diagnostic information to physicians and their patients worldwide, as well as proprietary products that serve laboratories worldwide. Through its collaborations with world-class academic institutions specializing in cancer research, diagnostics and treatment, Precipio offers a new standard of diagnostic accuracy enabling the highest level of patient care. For more information, please visit www.precipiodx.com.
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